What is DIM (Diindolylmethane)?

Diindolylmethane (DIM) is a phytonutrient that is released in the body when gastric acid from the digestive process acts on indole-3-carbinol, the precursor to DIM. Research shows that DIM has the ability to promote and support metabolism of estrogen and related hormones by enhancing the liver’s ability to metabolize estrogen to a weaker factor called 2-hydroxyestrone, which helps protect prostate tissue from inflammation and cancer.

A Wayne State University School of Medicine study reported that DIM and I3C inhibited prostate cancer cell growth and also promoted cell suicide (apoptosis). (Sarkar 2004) DIM may also benefit men who suffer with BPH by reducing nighttime urination. (Zeligs)

Although both DIM and indole-3-carbinol are available as supplements, absorbable DIM is recommended because the body is much better able to absorb DIM, whereas only about 10 percent of indole-3-carbinol is converted to DIM in the gut.



Sarkar FH, Li Y. Indole-3-carbinol and prostate cancer. J Nutr 2004 Dec; 134(12 Supp): 3493S-98S

Zeligs MA. The cruciferous choice: diindolylmethane or I3C? Access at http://www.dimfaq.com/site/cruchoice.htm