Causes of Erectile Dysfunction

Drugs and Medications That Cause ED

Drugs and medications that cause ED or other sexual problems

Medically reviewed by Dr. Larry Lipshultz M.D

If you are taking medications and also suffering from ED, you should consult your doctor to see if any of the drugs may be a cause of the problem. This also includes the use of illicit and/or recreational drugs. Drugs and medications that cause ED or other sexual problems as side effects are commonly prescribed for men without them knowing the risks. For example, you might want more hair on your head or relief from urinary symptoms associated with an enlarged prostate, but perhaps not at the expense of your sexual function, either long-term or permanently. Yet some of the drugs prescribed for these conditions can result in impotence.

What Are Drugs Medications That Cause ED?

Drugs that cause erectile dysfunction include those in the following classifications.


Note that although the vast majority of the drugs associated with erectile dysfunction are prescription, a few can be obtained over the counter. Therefore, do not assume any over-the-counter medications you may be taking are safe.

Be sure to read the labels of all medications carefully before you take them, and ask your doctor or pharmacist if you are uncertain about any ingredients. The following are drugs and medications that cause ED or other sexual problems:

5-alpha reductase inhibitors: dutasteride, finasteride (drugs used to treat enlarged prostate)

Alpha-blockers: Although alpha-blockers generally are not among drugs that cause erectile dysfunction, one drug commonly prescribed to treat an enlarged prostate, tamsulosin (Flomax) has been shown in studies to cause ED

Antiarrhythmics: disopyramide

Anticholinergics: darifenacin, fesoterodine, oxybutynin, tolterodine

Antidepressants, antianxiety, antiepileptics: fluoxetine, tranylcypromine, sertraline, isocarboxazid, amitriptyline, amoxipine, clomipramine, desipramine, nortriptyline, phenelzine, buspirone, chlordiazepoxide, clorazepate, diazepam, dosxepin, imipramine, lorazepam, oxazepam, phenytoin

Antihistamines: dimehydrinate, diphenhydramine, hydroxyzine, meclizine, promethazine

Chemotherapy drugs: busulfan, cyclophosphamide

Diuretics and antihypertensives: hydrochlorothiazide, chlorthalidone, triamterene, furosemide, bumetanide, guanfacine, methyldopa, clonidine, verapamil, nifedipine, hydralazine, captopril, enalapril, metoprolol, propranolol, labetalol, atenolol, phenoxybenzamine, spironolactone

Histamine H2-receptor antagonists: cimetidine, nizatidine, ranitidine

Illicit and/or recreational drugs: cocaine, crystal meth, heroin, marijuana, methamphetamines

Muscle relaxants: cyclobenzaprine, orphenadrine

Nonsteroidal anti-inflammatory drugs: naproxen, indomethacin

Parkinson’s disease medications: biperiden, benztropine, trihexyphenidyl, procyclidine, bromocriptine, levodopa

Prostate cancer medications: flutamide, leuprolide

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