Bromelain for Peyronie’s disease is a combination of enzymes, found in the stem and juice of pineapples (Ananas comosus), that have the ability to digest protein. Among the proteins it may break down is collagen, which is the main component in the plaque associated with Peyronie’s disease. Bromelain reportedly can dissolve the peptide bonds that keep the proteins together.
The possibility of bromelain being able to digest collagen makes it a potential candidate for treatment of Peyronie’s disease, and some people do use it for that purpose. One animal study has suggested that bromelain promotes the secretion of the enzyme collagenase, which helps dissolve collagen. (Werb 1978)
However, no scientific studies have shown bromelain is effective in digesting collagen in humans, nor in eliminating plaque or relieving the symptoms of Peyronie’s disease.
No dose of bromelain has been established for treatment by bromelain for Peyronie’s disease. Side effects associated with the use of bromelain may include diarrhea, nausea, and vomiting. If you want to try taking bromelain to treat Peyronie’s disease, talk to a knowledgeable healthcare provider.
Werb Z, Aggeler J. Proteases induce secretion of collagenase and plasminogen activator by fibroblasts. Proc Natl Acad Sci USA 1978; 75