Can Saw Palmetto Shrink the Prostate?


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Many claims have been made about the ability of saw palmetto (Serenoa repens) , a natural remedy derived from the American dwarf palm tree, to shrink the prostate and relieve symptoms of an enlarged prostate (BPH) and associated urinary tract problems, as well as showing promise in prostatitis and perhaps even in fighting prostate cancer. But is this hype, or does saw palmetto really work to shrink the prostate?

Can saw palmetto shrink the prostate?

The simple answer to the question is yes, saw palmetto has been shown to be effective in managing BPH symptoms (including urinary tract symptoms) and prostatitis, and it’s too early to tell how effective it may be in the fight against prostate cancer. But here is why saw palmetto works.

One of the main components is beta-sitosterol, a substance that inhibits the activity of an enzyme called 5-alpha-reductase. This enzyme promotes the growth of prostate cells, and thus contributes to an enlarged prostate. Saw palmetto also appears to reduce levels of dihydrotestosterone (DHT), a hormone which, at elevated levels, causes the prostate to become enlarged.

To get a better idea of how saw palmetto has performed in men with BPH or prostatitis, here are the highlights of some of the research.

Saw palmetto for BPH and prostatitis

The most recent (published April 2018) research on the effect of saw palmetto on BPH comes from a systematic review and meta-analysis that evaluated data from 27 studies and 5,800 participants. All of the studies analyzed used a proprietary saw palmetto product which contained 160 mg of lipidosterolic extract of Serenoa repens per capsule.

After evaluation, the reviewers reported that:

  • When compared with placebo, the saw palmetto supplement was associated with fewer voids during the night and an increase in peak urinary flow
  • When compared with the BPH drug tamsulosin, the two showed similar increases in peak urinary flow
  • When compared with alpha blockers, the two showed similar improvements on IPSS (International Prostate Symptom Score)
  • Prostate volume decreased slightly
  • Of the 447 men treated for one year or longer, efficacy results remained the same
  • The most frequent adverse reaction was gastrointestinal disorders (mean incidence, 3.8%)

The reviewers concluded that saw palmetto “appears to be an efficacious and well-tolerated therapeutic option for the long-term medical treatment of LUTS/BPH.” (Vela-Navarrete)

An April 2012 pilot study reported on the effect of saw palmetto on BPH and sexual dysfunctions in a group of 82 men. During the 8-week open trial, the men took one capsule of 320 mg saw palmetto extract daily. By the end of treatment, the men’s International Prostate Symptom Score (IPSS) had declined from 14.4 to 6.9, while their Sexual Function Inventory improved from 22.4 to 31.4. Quality of life also showed improvement on the Urolife BPH QoL-9 scale (from 162.7 to 105.0). This study was reportedly the first with saw palmetto to show improvement in symptoms of BPH and sexual dysfunction. (Suter)

A long-term (24-month) study of saw palmetto was conducted in 120 men with mild or moderate lower urinary tract symptoms associated with BPH. After taking 320 mg of saw palmetto daily, the men showed statistically significant improvement in their IPSS, quality of life, residual urinary volume, prostate volume, and sexual function. (Sinescu)

Saw palmetto compared to Flomax results

What happens when you compare saw palmetto with a conventional BPH treatment such as tamsulosin (Flomax)? A one-year study published in European Urology reported on the results of this comparison conducted in 704 men. Both saw palmetto and tamsulosin led to similar improvements in symptoms, although men who took tamsulosin were more likely to experience ejaculation disorders and to experience less improvement in prostate volume. (Debruyne)

A head-to-head comparison between saw palmetto v Flomax (tamsulosin) for men with chronic prostatitis also yielded positive results. A total of 157 men with chronic prostatitis were randomly assigned to take either 160 mg saw palmetto twice daily or 0.4 mg tamsulosin for six weeks. At the end of the study period, men in both groups experienced similar improvements in their Chronic Prostatitis Symptom Index (CPSI) scores, although men who took saw palmetto had an additional benefit: a greater decline in their pain scores. (Kravchick 2012)

Saw palmetto as combination treatment for BPH

Saw palmetto also works well when combined with other selected supplements. In a 2017 Cochrane review of saw palmetto both as a solo therapy and in combination, the authors concluded that “the totality of evidence includes favorable patients’ response from clinical experience, impact of placebo effect, early positive studies…and potential synergistic effects when combined with other therapies.” Those combinations include saw palmetto with lycopene and selenium as well as with stinging nettle. (Ooi)

One example can be seen in a clinical trial of 257 men who were experiencing lower urinary tract symptoms (LUTS) associated with BPH. The men were randomly assigned to take either placebo or a combination of 160 mg saw palmetto extract and 120 mg stinging nettle root extract daily for 24 weeks, followed by a 24-week control period and a 48-week period during which all the men took the combination. By the end of the study (week 96), the researchers reported a 53% improvement in the International Prostate Symptom Score (IPSS), a 19% improvement in urinary flow, and a 44% reduction in residual urine volume. (Lopatkin)

A subsequent study involved the use of saw palmetto along with stinging nettle, quercetin, and curcumin versus the antibiotic prulifloxacin in men who had chronic bacterial prostatitis. A total of 143 men were enrolled in the study, and they were randomly assigned to one of two groups: 106 received 600 mg prulifloxacin plus the four extracts for 14 days, while 37 men received the antibiotic only.

One month later, 89.6% of the men who took saw palmetto and the other supplements had no symptoms of prostatitis compared with only 27% of the men who took the antibiotic only. At a six-month follow-up, none of the men who had taken the herbal supplements and two who had taken the antibiotic alone had recurrent prostatitis. (Cai)

According to Dr. Geo Espinosa, ND, Lac, CNS, RH (AHG), director of the Integrative Urological Center at New York University Langone Medical Center, “The studies with saw palmetto and other herbal supplements strongly suggest a saw palmetto combination can lead to enhanced results when managing symptoms of BPH and prostatitis.”

In fact, failure to use saw palmetto in combination with other selected supplements is likely why some studies of saw palmetto for management of BPH have not yielded good results, according to Dr. Espinosa. A case in point is a Cochrane review (May 2012) that evaluated 17 randomized controlled trials (2,008 participants) comparing saw palmetto (usually 320 mg/day) with placebo. The reviewers found that saw palmetto was no better than placebo in improving lower urinary tract symptoms (LUTS).

Saw palmetto and prostate cancer

The potential for using saw palmetto in the fight against prostate cancer is still largely unknown, although some research has been done. In particular, two Italian studies reported that prostate cells treated with the extract underwent cell death (apoptosis). (Baron; Petrangeli)

Another study conducted at the Fred Hutchinson Cancer Research Center was not as positive. Data in the study came from 35,239 men who had participated in the VITamins and Lifestyle (VITAL) project. The investigators looked at the men’s supplement use and incidence of prostate cancer and did not find an association for use of saw palmetto. (Brasky)

Taking saw palmetto to shrink the prostate

Research indicates that 320 mg daily of saw palmetto is an effective dose. Saw palmetto taken with other selected herbal remedies, including quercetin, stinging nettle, and curcumin, may enhance the benefits. Side effects associated with the use of saw palmetto are generally mild and may include back pain and headache.

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References

Baron A et al. Sereona repens extract targets mitochondria and activates the intrinsic apoptotic pathway in human prostate cancer cells. BJU Int 2009 May; 103(9): 1275-83

Brasky TM et al. Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort. Nutr Cancer 2011; 63(4): 573-82

Cai T et al. Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomized study. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53

Debruyne Fet al. Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study. Eur Urol 2002; 41(5):497-506.

Kravchick SG et al at the 27th Annual European Association of Urology Congress, February 24-28, 2012, Paris, France.

Lopatkin N et al. Efficacy and safety of a combination of Sabal and Urtica extract in lower urinary tract symptoms—long-term follow-up of a placebo-controlled, double-blind, multicenter trial. Int Urol Nephrol 2007; 39(4): 1137-46.

Macdonald R et al. Serenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic review. BJU Int 2012 May 2. Can saw palmetto shrink the prostate

Ooi SL, Pak SC. Serenoa repens for lower urinary tract symptoms/benign prostatic hyperplasia: current evidence and its clinical implications in naturopathic medicine. Journal of Alternative and Complementary Medicine 2017 Aug; 23(8): 59-606

Petrangeli E et al. Lipido-sterolic extract of Serenoa repens (LSESr, Permixon) treatment affects human prostate cancer cell membrane organization. J Cell Physiol 2009 Apr; 219(1): 69-76.

Sinescu I et al. Long-term efficacy of serenoa repens treatment in patients with mild and moderate symptomatic benign prostatic hyperplasia. Urol Int 2011; 86(3): 284-49

Suter A et al. Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial. Phytotherapy Research 2013 Feb; 27(2): 218-26. Can saw palmetto shrink the prostate.

Vela-Navarrete R et al. Efficacy and safety of a hexanic extract of Serenoa repens (Permixon® ) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): Systematic review and meta-analysis of randomized controlled trials and observational studies. BJU Int. 2018 Apr 25


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